diff --git a/ext/sqlite/libsqlite/src/os.c b/ext/sqlite/libsqlite/src/os.c
index 2c57078305b..12761bb2a32 100644
--- a/ext/sqlite/libsqlite/src/os.c
+++ b/ext/sqlite/libsqlite/src/os.c
@@ -34,6 +34,9 @@
 # ifndef O_BINARY
 #  define O_BINARY 0
 # endif
+# ifndef EISDIR
+#  define EISDIR 21
+# endif
 #endif
 
 
@@ -464,6 +467,9 @@ int sqliteOsOpenReadWrite(
   id->dirfd = -1;
   id->fd = open(zFilename, O_RDWR|O_CREAT|O_LARGEFILE|O_BINARY, 0644);
   if( id->fd<0 ){
+    if (errno == EISDIR) {
+      return SQLITE_CANTOPEN;
+    }
     id->fd = open(zFilename, O_RDONLY|O_LARGEFILE|O_BINARY);
     if( id->fd<0 ){
       return SQLITE_CANTOPEN;