diff --git a/NEWS b/NEWS
index 03b3ac758fd..11b9214b683 100644
--- a/NEWS
+++ b/NEWS
@@ -149,6 +149,10 @@ PHP                                                                        NEWS
 - PCRE:
   . Fix UAF issues with PCRE after request shutdown. (nielsdos)
 
+- PDO_MYSQL:
+  . Fixed GH-15949 (PDO_MySQL not properly quoting PDO_PARAM_LOB binary
+    data). (mbeccati, lcobucci)
+
 - PDO_PGSQL:
   . Fixed GH-15986 (Double-free due to Pdo\Pgsql::setNoticeCallback()). (cmb,
     nielsdos)
diff --git a/UPGRADING b/UPGRADING
index 40117191257..d84c31f96ea 100644
--- a/UPGRADING
+++ b/UPGRADING
@@ -184,6 +184,9 @@ PHP 8.4 UPGRADE NOTES
 - PDO_MYSQL:
   . getAttribute, ATTR_AUTOCOMMIT, ATTR_EMULATE_PREPARES, MYSQL_ATTR_DIRECT_QUERY have
     been changed to get values as bool.
+  . Quoting a string with PARAM_LOB as type now outputs the string explicitly quoted
+    as binary. This also affects parameters bound as PARAM_LOB when
+    ATTR_EMULATE_PREPARES is enabled.
 
 - PDO_PGSQL:
   . The DSN's credentials, when set, are given priority over their PDO
diff --git a/ext/pdo_mysql/mysql_driver.c b/ext/pdo_mysql/mysql_driver.c
index f75959fce0c..3bdb335a4a9 100644
--- a/ext/pdo_mysql/mysql_driver.c
+++ b/ext/pdo_mysql/mysql_driver.c
@@ -309,23 +309,29 @@ static zend_string* mysql_handle_quoter(pdo_dbh_t *dbh, const zend_string *unquo
 {
 	pdo_mysql_db_handle *H = (pdo_mysql_db_handle *)dbh->driver_data;
 	bool use_national_character_set = 0;
+	bool use_binary = 0;
 	size_t quotedlen;
 
-	if (H->assume_national_character_set_strings) {
-		use_national_character_set = 1;
-	}
-	if ((paramtype & PDO_PARAM_STR_NATL) == PDO_PARAM_STR_NATL) {
-		use_national_character_set = 1;
-	}
-	if ((paramtype & PDO_PARAM_STR_CHAR) == PDO_PARAM_STR_CHAR) {
-		use_national_character_set = 0;
+	if ((paramtype & PDO_PARAM_LOB) == PDO_PARAM_LOB) {
+		use_binary = 1;
+	} else {
+		if (H->assume_national_character_set_strings) {
+			use_national_character_set = 1;
+		}
+		if ((paramtype & PDO_PARAM_STR_NATL) == PDO_PARAM_STR_NATL) {
+			use_national_character_set = 1;
+		}
+		if ((paramtype & PDO_PARAM_STR_CHAR) == PDO_PARAM_STR_CHAR) {
+			use_national_character_set = 0;
+		}
 	}
 
 	PDO_DBG_ENTER("mysql_handle_quoter");
 	PDO_DBG_INF_FMT("dbh=%p", dbh);
 	PDO_DBG_INF_FMT("unquoted=%.*s", (int)ZSTR_LEN(unquoted), ZSTR_VAL(unquoted));
 
-	zend_string *quoted_str = zend_string_safe_alloc(2, ZSTR_LEN(unquoted), 3 + (use_national_character_set ? 1 : 0), false);
+	zend_string *quoted_str = zend_string_safe_alloc(2, ZSTR_LEN(unquoted),
+		3 + (use_national_character_set ? 1 : 0) + (use_binary ? 7 : 0), false);
 	char *quoted = ZSTR_VAL(quoted_str);
 
 	if (use_national_character_set) {
@@ -334,6 +340,11 @@ static zend_string* mysql_handle_quoter(pdo_dbh_t *dbh, const zend_string *unquo
 		quoted[1] = '\'';
 
 		++quotedlen; /* N prefix */
+	} else if (use_binary) {
+		quotedlen = mysql_real_escape_string_quote(H->server, quoted + 8, ZSTR_VAL(unquoted), ZSTR_LEN(unquoted), '\'');
+		memcpy(quoted, "_binary'", 8);
+
+		quotedlen += 7; /* _binary prefix */
 	} else {
 		quotedlen = mysql_real_escape_string_quote(H->server, quoted + 1, ZSTR_VAL(unquoted), ZSTR_LEN(unquoted), '\'');
 		quoted[0] = '\'';
diff --git a/ext/pdo_mysql/tests/pdo_mysql_prepare_emulated_binary.phpt b/ext/pdo_mysql/tests/pdo_mysql_prepare_emulated_binary.phpt
index fe198376d61..9d291299843 100644
--- a/ext/pdo_mysql/tests/pdo_mysql_prepare_emulated_binary.phpt
+++ b/ext/pdo_mysql/tests/pdo_mysql_prepare_emulated_binary.phpt
@@ -13,6 +13,10 @@ MySQLPDOTest::skip();
     $db = MySQLPDOTest::factory();
     $db->setAttribute(PDO::ATTR_EMULATE_PREPARES, true);
 
+    // Force the connection to utf8, which is enough to make the test fail
+    // MySQL 5.6+ would be required for utf8mb4
+    $db->exec("SET NAMES 'utf8'");
+
     $content = '0191D886E6DC73E7AF1FEE7F99EC6235';
 
     $statement = $db->prepare('SELECT HEX(?) as test');
diff --git a/ext/pdo_mysql/tests/pdo_mysql_quote_binary.phpt b/ext/pdo_mysql/tests/pdo_mysql_quote_binary.phpt
new file mode 100644
index 00000000000..9c81f084909
--- /dev/null
+++ b/ext/pdo_mysql/tests/pdo_mysql_quote_binary.phpt
@@ -0,0 +1,28 @@
+--TEST--
+MySQL PDO->quote(), properly handle binary data
+--EXTENSIONS--
+pdo_mysql
+--SKIPIF--
+<?php
+require_once __DIR__ . '/inc/mysql_pdo_test.inc';
+MySQLPDOTest::skip();
+?>
+--FILE--
+<?php
+    require_once __DIR__ . '/inc/mysql_pdo_test.inc';
+    $db = MySQLPDOTest::factory();
+    $db->setAttribute(PDO::ATTR_EMULATE_PREPARES, true);
+
+    // Force the connection to utf8, which is enough to make the test fail
+    // MySQL 5.6+ would be required for utf8mb4
+    $db->exec("SET NAMES 'utf8'");
+
+    $content = "\xC3\xA1\xC3";
+    $quoted = $db->quote($content, PDO::PARAM_LOB);
+
+    var_dump($quoted);
+    var_dump($db->query("SELECT HEX({$quoted})")->fetch(PDO::FETCH_NUM)[0]);
+?>
+--EXPECTF--
+string(%d) "_binary'%s'"
+string(6) "C3A1C3"